Collagen-Based Wound Matrices

---

Collagen-based wound matrices are especially useful for chronic, hard-to-heal wounds such as diabetic foot ulcers, venous leg ulcers, pressure injuries, and surgical wounds. By providing structure and support where the body struggles to repair itself, these products play a vital role in achieving better healing outcomes.

• Composed of reconstituted Type I collagen derived from equine tendon, chemically cross-linked to resist early proteolytic degradation.  
• Sterile, conformable, porous, hydrophilic scaffold that can absorb fluids (≈0.5 cc per cm²) and conform closely to wound beds.  
• Stabilized collagen matrix allows the product to remain intact longer, reducing the need for frequent reapplications.  
• Room-temperature storage (dry), no need for refrigeration. Long shelf life.  
• Minimal preparation: hydrated in sterile saline before application, ready to use.  
• Biocompatible and cell-friendly; designed to integrate with host tissue over time (gradual remodeling) while supporting new tissue growth. 

• Helicoll is an acellular collagen matrix derived from bovine tissue (as described in wound-care product comparisons).
• Provides structural collagen scaffolding to support tissue regeneration, while minimizing immunogenic components due to decellularization.
• Designed to be biocompatible, supporting host cell infiltration and integration.
• Enables ease of handling and conformability to wound beds. (wound dressing)

• Human or xenogeneic dermal extracellular matrix scaffold
• Maintains collagen and elastin microstructure to support tissue regeneration.
• Decellularized to reduce immunogenicity; retains native architecture.
• Flexible, suturable, easy to handle.

• ACA could mean “Acellular Collagen Allograft” or similar.
• Provides structural ECM support.
• Low immunogenic profile.

• Emphasis on “therapeutic” healing — antimicrobial, anti-inflammatory, or growth-factor enriched features.
• May combine ECM with therapeutic additives.